Preheat your oven to 170°F (77°C) and line a baking sheet with parchment paper.
In a large mixing bowl, combine the ground beef with all the spices: smoked paprika, garlic powder, onion powder, black pepper, red pepper flakes, salt, sugar, coriander, and cumin. Mix well until all ingredients are thoroughly incorporated.
Add the vinegar, water, and mustard to the meat mixture. Continue to mix until the mixture is smooth and sticky.
Spread the beef mixture evenly onto the prepared baking sheet, pressing it down to about 1/4 inch thick. Use a spatula to smooth the surface.
Using a sharp knife or pizza cutter, score the meat into slices (about 1 inch wide) to make it easier to break apart later.
Place the baking sheet in the preheated oven and let it dry out for about 4-6 hours, or until the beef is firm and slightly dry to the touch. Check periodically to ensure it doesn’t over-dry.
Once done, remove the baking sheet from the oven and let the pepperoni cool completely. Break apart the slices along the scored lines.
Store the sliced pepperoni in an airtight container in the refrigerator for up to a week or freeze for longer storage.